Low-power, low-cost urinalysis system with integrated dipstick evaluation and microscopic analysis. Issue 14 (21st June 2018)

• Record Type: Journal Article
• Authors: Smith, Gennifer T.; Li, Linkai; Zhu, Yue; Bowden, Audrey K.
• Is Part Of: Lab on a chip. Volume 18:Issue 14(2018)
• Page Start: 2111
• Page End: 2123
• Publication Date: 2018-06-21
• Subjects: Miniature electronic equipment -- Periodicals; Combinatorial chemistry -- Periodicals; Biotechnology -- Periodicals; 543.0813
• DOI: 10.1039/c8lc00501j
• Languages: English
• ISSNs: 1473-0197

Abstract

Abstract : A device for coupled dipstick and microscopy urinalysis with the potential to be an at-home or low-resource platform. Abstract : We introduce a coupled dipstick and microscopy device for analyzing urine samples. The device is capable of accurately assessing urine dipstick results while simultaneously imaging the microscopic contents within the sample. We introduce a long working distance, cellphone-based microscope in combination with an oblique illumination scheme to accurately visualize and quantify particles within the urine sample. To facilitate accurate quantification, we couple the imaging set-up with a power-free filtration system. The proposed device is reusable, low-cost, and requires very little power. We show that results obtained with the proposed device and custom-built app are consistent with those obtained with the standard clinical protocol, suggesting the potential clinical utility of the device.