An electrospun poly(ε-caprolactone) nanocomposite fibrous mat with a high content of hydroxyapatite to promote cell infiltration. Issue 44 (16th July 2018)

• Record Type: Journal Article
• Authors: Li, Haoxuan; Huang, Chen; Jin, Xiangyu; Ke, Qinfei
• Is Part Of: RSC advances. Volume 8:Issue 44(2018)
• Page Start: 25228
• Page End: 25235
• Publication Date: 2018-07-16
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra02059k
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : PCL nanofibers with 60% HAp content were fabricated, and the presence of HAp regulated cell morphology to enhance cell infiltration. Abstract : Electrospun polymer/inorganic biomimetic nanocomposite scaffolds have emerged for use in a new strategy for bone regeneration. In this study, a poly(ε-caprolactone) (PCL)/hydroxyapatite (HAp) nanocomposite mat with a HAp content as high as 60% was prepared via one-step electrospinning using trifluoroethanol as the solvent, and it has superior dispersibility and spinnability. The structure and physicochemical properties of the scaffolds were studied using scanning electron microscopy and spectroscopic techniques. X-ray diffraction and Fourier transformed infrared spectroscopy confirmed the presence of HAp in the composite PCL fibers. The results of cell culturing suggested that the incorporation of HAp with PCL could regulate the cytoskeleton and the differentiation of cells. More interestingly, the high content of HAp was also found to be conducive to the infiltration of MC-3T3 cells into the mat. The results indicated the potential of PCL/HAp scaffolds as a promising substitute for bone regeneration.