A novel near-infrared fluorescent probe for highly selective recognition of hydrogen sulfide and imaging in living cells. Issue 42 (2nd July 2018)

• Record Type: Journal Article
• Authors: Zhong, Keli; Deng, Longlong; Zhao, Jie; Yan, Xiaomei; Sun, Tong; Li, Jianrong; Tang, Lijun
• Is Part Of: RSC advances. Volume 8:Issue 42(2018)
• Page Start: 23924
• Page End: 23929
• Publication Date: 2018-07-02
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra03457e
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A novel "off–on" fluorescent probe (L ) for H2 S detection with NIR emission and imaging H2 S in living cells. Abstract : A novel near-infrared fluorescent probe (L ) based on a 1, 4-diethyl-1, 2, 3, 4-tetrahydro-7 H -pyrano[2, 3- g ]quinoxalin-7-one scaffold has been synthesized and characterized. ProbeL displays highly selective and sensitive recognition to H2 S over various anions and biological thiols with a large Stokes shift (125 nm) in THF/H2 O (6/4, v/v, Tris–HCl 10 mM, pH = 7.4). This probe exhibits turn-on fluorescence for H2 S through HS − induced thiolysis of dinitrophenyl ether. Confocal laser scanning micrographs of MCF-7 cells incubated withL confirm thatL is cell-permeable and can successfully detect H2 S in living cells.