Colorimetric sensor for cimetidine detection in human urine based on d-xylose protected gold nanoparticles. Issue 10 (26th April 2018)

• Record Type: Journal Article
• Authors: Hu, Fan; Wu, PinPing; Wang, RuYa; Liu, Wei; He, Hua
• Is Part Of: Analyst. Volume 143:Issue 10(2018)
• Page Start: 2369
• Page End: 2376
• Publication Date: 2018-04-26
• Subjects: Chemistry, Analytic -- Periodicals; 543
• DOI: 10.1039/c8an00499d
• Languages: English
• ISSNs: 0003-2654

Abstract

Abstract : A simple, novel, and rapid colorimetric sensor for cimetidine (Cim) detection based ond -xylose protected gold nanoparticles (d -x@AuNPs) has been developed for the first time. Abstract : Herein, a simple, novel, and rapid colorimetric sensor for cimetidine (Cim) detection based ond -xylose protected gold nanoparticles (d -x@AuNPs) has been developed for the first time. Thed -x@AuNPs were characterized by UV-vis, TEM and FT-IR techniques. Cimetidine causes the aggregation ofd -x@AuNPs due to the formation of a strong covalent Au–N bond and electrostatic binding. As the cimetidine concentration increased, the color of the solutions gradually changed from wine-red to blue, and the large absorption band shifted from 533 to 680 nm upond -x@AuNP aggregation. The effects of different experimental parameters were investigated. A comparative study on the detection of Cim using citrated capped AuNPs andd -x@AuNPs was presented. Under optimum conditions, the UV-vis spectra showed that the absorption ratio ( A 680 / A 533 ) increased linearly with the concentration of cimetidine in the range of 7 × 10 −8 to 3 × 10 −6 M with a correlation coefficient of 0.9956 and a limit of detection of 1 × 10 −8 M without needing any complicated instruments. The selectivity of thed -x@AuNP detection system for cimetidine was excellent when compared with other ions and analytes. Due to their rapid and visible color changes, and their remarkable selectivity, thed -x@AuNPs synthesized in this study were suitable and could be applied to the detection of cimetidine in human urine.