Auto-oxidation promoted sp3 C–H arylation of glycine derivatives. Issue 27 (25th June 2018)

• Record Type: Journal Article
• Authors: Wei, Yuanyuan; Wang, Jie; Wang, Yajun; Yao, Xiaoqiang; Yang, Caixia; Huo, Congde
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 27(2018)
• Page Start: 4985
• Page End: 4989
• Publication Date: 2018-06-25
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob01068d
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An auto-oxidation promoted sp 3 C–H arylation reaction between N -aryl glycine derivatives and electron-rich arenes, leading to the formation of N -aryl α-aryl α-amino acid derivatives, is described. This atom-economical and environmentally benign reaction proceeds smoothly under mild reaction conditions and requires only Brønsted acid and oxygen (balloon). A plausible radical involved mechanism is proposed. Abstract : An auto-oxidation promoted sp 3 C–H arylation reaction between N -aryl glycine derivatives and electron-rich arenes, leading to the formation of N -aryl α-aryl α-amino acid derivatives, is described. This atom-economical and environmentally benign reaction proceeds smoothly under mild reaction conditions and requires only Brønsted acid and oxygen (balloon). A plausible radical involved mechanism is proposed.