Lysosome-targeting ratiometric fluorescent pH probes based on long-wavelength BODIPY. Issue 27 (28th June 2018)

• Record Type: Journal Article
• Authors: Zhu, Mengliang; Xing, Peipei; Zhou, Yabin; Gong, Lei; Zhang, Jinghui; Qi, Dongdong; Bian, Yongzhong; Du, Hongwu; Jiang, Jianzhuang
• Is Part Of: Journal of materials chemistry. Volume 6:Issue 27(2018)
• Page Start: 4422
• Page End: 4426
• Publication Date: 2018-06-28
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c8tb00883c
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : BODIPY-based ratiometric fluorescent probes show remarkable sensitivity under acidic conditions via a protonation-modulated ICT mechanism for monitoring lysosomal pH in living cells. Abstract : BODIPY-based probes were developed for the ratiometric fluorescence detection of pH values. They showed high sensitivity under acidic conditions via a protonation-modulated ICT mechanism and could selectively stain lysosomes, and thus could be applied for imaging and detecting abnormal pH decreases in live cells.