Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans. Issue 27 (27th June 2018)

• Record Type: Journal Article
• Authors: Lin, Haizhou; Lyu, Haining; Zhou, Shuang; Yu, Jingwen; Keller, Nancy P.; Chen, Lin; Yin, Wen-Bing
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 27(2018)
• Page Start: 4973
• Page End: 4976
• Publication Date: 2018-06-27
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob01326h
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : By disruption of LaeB, a global regulator recently characterized in Aspergillus nidulans, eight cryptic compounds in the mutant were identified, including seven polyketides and one NRPS-like product. Abstract : By disruption of LaeB, a global regulator recently characterized in Aspergillus nidulans, eight cryptic compounds in the mutant were identified, including seven polyketides and one NRPS-like product. Among the isolates, two phthalides and two dibenzo[1, 4]dioxins are new compounds, revealing that the genetic manipulation of the global regulator represents a promising approach for the discovery of novel natural products in fungi.