UV365 light promoted catalyst-free synthesis of pyrimido[4, 5-b]quinoline-2, 4-diones in aqueous-glycerol medium. (10th May 2018)

• Record Type: Journal Article
• Authors: Nongthombam, Geetmani Singh; Kharmawlong, George Kupar; Kumar, John Elisa; Nongkhlaw, Rishanlang
• Is Part Of: New journal of chemistry. Volume 42:Number 12(2018)
• Page Start: 9436
• Page End: 9442
• Publication Date: 2018-05-10
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c8nj01459k
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Herein, a highly efficient and environmentally benign protocol for the synthesis of biologically important pyrimido[4, 5- b ]quinolinone-2, 4-diones from aromatic amines, barbituric acid and aryl aldehyde is reported. Abstract : Herein, a highly efficient and environmentally benign protocol for the synthesis of biologically important pyrimido[4, 5- b ]quinolinone-2, 4-diones from aromatic amines, barbituric acid and aryl aldehyde is reported. This process takes place at room temperature under direct irradiation from a UV365 light source in the absence of a photocatalyst. The reported approach has several advantages such as high yield, clean reaction conditions, chromatography-free synthesis and the use of a cheap water–glycerol solvent system, which is also an environmentally friendly solvent. The applicability of this protocol for the large-scale synthesis of pyrimido[4, 5- b ]quinolinone-2, 4-diones without wasting any expensive chemicals is an added advantage.