A simple two-photon turn-on fluorescent probe for the selective detection of cysteine based on a dual PeT/ICT mechanism. Issue 24 (10th April 2018)

• Record Type: Journal Article
• Authors: Chen, Xiani; Xu, Hang; Ma, Shengnan; Tong, Hongjuan; Lou, Kaiyan; Wang, Wei
• Is Part Of: RSC advances. Volume 8:Issue 24(2018)
• Page Start: 13388
• Page End: 13392
• Publication Date: 2018-04-10
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra02138d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : N -(6-acyl-2-naphthayl)-maleimide (1 ) is a simple two-photon fluorescent probe with selectivity for cysteine, based on a thiol-Michael-addition-transcyclization cascade and dual PeT/ICT quenching mechanism. Abstract : Herein, a simple two-photon turn-on fluorescent probe, N -(6-acyl-2-naphthayl)-maleimide (1 ), based on a dual PeT/ICT quenching mechanism is reported for the highly sensitive and selective detection of cysteine (Cys) over other biothiols. The probe was applied in the two-photon imaging of Cys in cultured HeLa cells, excited by a near-infrared laser at 690 nm.