Octahedral molybdenum clusters as radiosensitizers for X-ray induced photodynamic therapy. Issue 26 (21st June 2018)

• Record Type: Journal Article
• Authors: Kirakci, Kaplan; Zelenka, Jaroslav; Rumlová, Michaela; Martinčík, Jiří; Nikl, Martin; Ruml, Tomáš; Lang, Kamil
• Is Part Of: Journal of materials chemistry. Volume 6:Issue 26(2018)
• Page Start: 4301
• Page End: 4307
• Publication Date: 2018-06-21
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c8tb00893k
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : The nanoparticles made of the luminescent octahedral molybdenum cluster compound significantly enhance the antiproliferative effect of X-ray radiation. Abstract : The use of radiosensitizers recently emerged as a promising approach to circumvent the depth penetration limitations of photodynamic therapy of cancer and to enhance radiotherapeutical effects. A widely explored current strategy is based on complex nanoarchitectures that facilitate the transfer of energy harvested from X-ray radiation by scintillating nanoparticles to the surrounding photosensitizer molecules to generate reactive oxygen species, mostly singlet oxygen O2 ( 1 Δg ). We describe an alternative approach aiming at a considerable simplification of the architecture. The presented nanoparticles, made of the luminescent octahedral molybdenum cluster compound ( n -Bu4 N)2 [Mo6 I8 (OCOCF3 )6 ], efficiently absorb X-rays due to the high content of heavy elements, leading to the formation of the excited triplet states that interact with molecular oxygen to produce O2 ( 1 Δg ). The activity of the nanoparticles on HeLa cells was first investigated under UVA/blue-light irradiation in order to prove the biological effects of photosensitized O2 ( 1 Δg ); there is no dark toxicity at micromolar concentrations, but strong phototoxicity in the nanomolar range. The nanoparticles significantly enhance the antiproliferative effect of X-ray radiation in vitro at lower concentration than for previously reported O2 ( 1 Δg ) radiosensitizing systems and this effect is more pronounced on cancer HeLa cells than non-cancer MRC cells. The results demonstrate that the cluster-based radiosensitizers of O2 ( 1 Δg ) have strong potential with respect to the enhancement of the efficacy of radiotherapy with exciting opportunities for cancer treatment.