Preparation and photo-induced activities of water-soluble amyloid β-C60 complexes. Issue 32 (16th May 2018)

• Record Type: Journal Article
• Authors: Hasunuma, Naoki; Kawakami, Masahiro; Hiramatsu, Hirotsugu; Nakabayashi, Takakazu
• Is Part Of: RSC advances. Volume 8:Issue 32(2018)
• Page Start: 17847
• Page End: 17853
• Publication Date: 2018-05-16
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra02789g
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : We have shown that fullerene (C60 ) becomes soluble in water by mixing fullerene and amyloid β peptide (Aβ40) whose fibril structures are considered to be associated with Alzheimer's disease. Abstract : We have shown that fullerene (C60 ) becomes soluble in water by mixing fullerene and amyloid β peptide (Aβ40) whose fibril structures are considered to be associated with Alzheimer's disease. The water-solubility of fullerene arises from the generation of a nanosized complex between fullerene and the monomer species of Aβ40 (Aβ40-C60 ). The prepared Aβ40-C60 exhibits photo-induced activity with visible light to induce the inhibition of Aβ40 fibrillation and the cytotoxicity for cultured HeLa cells. The observed photo-induced phenomena result from the generation of singlet oxygen via photoexcitation, inducing oxidative damage to Aβ40 and HeLa cells. The oxidized Aβ40 following photoexcitation of Aβ40-C60 was confirmed by mass spectrometry.