HIAPP forms toxic oligomers in plasma. Issue 43 (10th May 2018)

• Record Type: Journal Article
• Authors: Rodriguez Camargo, Diana C.; Garg, Divita; Buday, Katalin; Franko, Andras; Rodriguez Camargo, Andres; Schmidt, Fabian; Cox, Sarah J.; Suladze, Saba; Haslbeck, Martin; Mideksa, Yonatan G.; Gemmecker, Gerd; Aichler, Michaela; Mettenleiter, Gabriele; Schulz, Michael; Walch, Axel Karl; Hrabě de Angelis, Martin; Feige, Matthias J.; Sierra, Cesar A.; Conrad, Marcus; Tripsianes, Konstantinos; Ramamoorthy, Ayyalusamy; Reif, Bernd
• Is Part Of: Chemical communications. Volume 54:Issue 43(2018)
• Page Start: 5426
• Page End: 5429
• Publication Date: 2018-05-10
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc03097a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Glucose and lipid containing particles such as LDL interact with hIAPP, resulting in the formation of hIAPP oligomeric structures that yield an intrinsic fluorescence and toxicity in cellular assays. Abstract : In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in β-sheet rich oligomers with increased β-cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases.