I2-Catalyzed intramolecular dehydrogenative aminooxygenation of alkynes to acylated imidazo[1, 2-a]pyridines and indolizines. Issue 11 (11th April 2018)

• Record Type: Journal Article
• Authors: He, Yimiao; Yin, Wenqing; Wang, Jian; Huang, Jianrong; Pang, Xinru; Gan, Chunfang; Yang, Fang; Huang, Chusheng
• Is Part Of: Organic chemistry frontiers. Volume 5:Issue 11(2018)
• Page Start: 1772
• Page End: 1776
• Publication Date: 2018-04-11
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c8qo00063h
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : An efficient and green protocol for the construction of acylated imidazo[1, 2- a ]pyridines and indolizines via intramolecular dehydrogenative aminooxygenation of alkynes has been developed. Abstract : An efficient and green protocol for the synthesis of acylated imidazo[1, 2- a ]pyridines and indolizines via intramolecular dehydrogenative aminooxygenation of alkynes has been developed. The reaction proceeds smoothly utilizing I2 as a catalyst and TBHP as an oxidant with a broad substrate scope. Mechanism studies reveal that the reaction maybe experiences a hydration followed by an oxidative cycloamination process.