A novel method to prepare tussah/Bombyx mori silk fibroin-based films. Issue 39 (15th June 2018)

• Record Type: Journal Article
• Authors: Yang, Richeng; Wu, Peng; Wang, Xinhong; Liu, Zekun; Zhang, Cong; Shi, Yinglu; Zhang, Feng; Zuo, Baoqi
• Is Part Of: RSC advances. Volume 8:Issue 39(2018)
• Page Start: 22069
• Page End: 22077
• Publication Date: 2018-06-15
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra03266a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A novel method is reported to prepare tussah/ Bombyx mori silk fibroin blend films featured transparent, flexible and biocompatible. Abstract : The possibility of using silk fibroin in biomaterials for tissue engineering is a subject of broad interest. In this study, Bombyx mori /tussah silk fibroin (BSF/TSF) blend films were prepared by solution casting using CaCl2 /formic acid as a co-solvent and water as a rinse solvent. The morphology, crystallinity, thermal resistance, mechanical properties and water contact angle of the blend films as well as the biocompatibility were investigated. The BSF/TSF blend films displayed a smooth surface and specific nanostructure in their cross-section, originating from the nanofibril-preservation during fibroin dissolution. The water rinse process induced the formation of a stable β-sheet structure. The BSF film showed superior mechanical properties to the TSF film, and the blending with TSF led to a significant reduction in the strength and elasticity of blend films. However, adding the TSF component could regulate the hydrophilic properties and enhance cell growth on the blend films. The BSF/TSF blend films with specific nanostructure, stable secondary structure, appropriate mechanical properties, and good biocompatibility, are promising candidates for application in regenerative medicine.