Lindera cyclopentenedione intermediates from the roots of Lindera aggregata. Issue 32 (16th May 2018)

• Record Type: Journal Article
• Authors: Chen, Lin; Liu, Bo; Deng, Jun-Jie; Zhang, Jun-Sheng; Li, Wei; Ahmed, Abrar; Yin, Sheng; Tang, Gui-Hua
• Is Part Of: RSC advances. Volume 8:Issue 32(2018)
• Page Start: 17898
• Page End: 17904
• Publication Date: 2018-05-16
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra03094d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Lindera cyclopentenediones together with their dimers and novel biosynthetic intermediates were isolated from Lindera aggregata . Abstract : Chromatographic fractionation of the roots of Lindera aggregata has led to the isolation of three new monomers of Lindera cyclopentenedione derivatives (1–3 ), a pair of new enantiomers of bi-linderone derivatives (4a /4b ), and six known Lindera cyclopentenediones (5–8 and9a /9b ). Their structures were determined by NMR and MS data. The absolute configurations of the new bi-linderone derivative enantiomers (4a /4b ) were determined by ECD calculation. (±)-Lindepentone A (1 ) presents the novel skeleton of 3, 5-dioxocyclopent-1-enecarboxylate. Lindoxepines A (2 ) and B (3 ) present an unprecedented oxepine-2, 5-dione derivative skeleton, which may be enlightening for the in vivo biosynthesis of the monomers of Lindera cyclopentenediones. A possible biosynthetic pathway for1 and a plausible biosynthetic pathway from stilbenes to Lindera cyclopentenediones via the key intermediates2 and3 were postulated. The inhibitory activity of these compounds against three microorganisms was also evaluated.