Aspect-ratio-dependent interaction of molecular polymer brushes and multicellular tumour spheroids. Issue 25 (15th June 2018)

• Record Type: Journal Article
• Authors: Müllner, Markus; Yang, Kylie; Kaur, Amandeep; New, Elizabeth J.
• Is Part Of: Polymer chemistry. Volume 9:Issue 25(2018)
• Page Start: 3461
• Page End: 3465
• Publication Date: 2018-06-15
• Subjects: Polymers -- Periodicals; Macromolecules -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1039/c8py00703a
• Languages: English
• ISSNs: 1759-9954

Abstract

Abstract : Molecular polymer brushes allow for independent tailoring of nanoparticle design parameters. Brush particles with altered shape and aspect ratio revealed that particle shape effects may be decoupled from surface chemistry to achieve higher tumour spheroid interaction and penetration. Abstract : Polymer nanoparticles based on molecular polymer brushes allow precise and independent tailoring of nanoparticle characteristics. This enables the synthesis of soft hydrophilic polymer particles with matching composition and surface chemistry where only the aspect-ratio is varied. PEGylated brush nanoparticles revealed that brush nanorods exhibit higher association and penetration into multicellular tumour spheroids compared to their spherical or filamentous counterparts.