A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1, 2-a][1, 3, 5]triazines12. Issue 38 (12th June 2018) - Lim, Felicia Phei Lin
Abstract : A highly selective, one-pot, three-component synthesis of novel 2-alkyl-substituted 4-aminoimidazo[1, 2- a ][1, 3, 5]triazines has been developed. Abstract : A highly selective, one-pot, three-component synthesis of novel 2-alkyl-substituted 4-aminoimidazo[1, 2- a ][1, 3, 5]triazines has been developed. The scope of the method was explored in two dimensions, varying the structures of trialkyl orthoesters and 2-aminoimidazoles in their reactions with cyanamide. Conveniently performed under microwave irradiation, this method was also proved to be efficient under conventional heating. A library of 24 novel compounds was prepared in high purity using this multicomponent approach. Molecular and crystal structures of representative molecules were studied using X-ray crystallography.