Chiral modulation of amyloid beta fibrillation and cytotoxicity by enantiomeric carbon dots. Issue 56 (27th June 2018)

• Record Type: Journal Article
• Authors: Malishev, Ravit; Arad, Elad; Bhunia, Susanta Kumar; Shaham-Niv, Shira; Kolusheva, Sofiya; Gazit, Ehud; Jelinek, Raz
• Is Part Of: Chemical communications. Volume 54:Issue 56(2018)
• Page Start: 7762
• Page End: 7765
• Publication Date: 2018-06-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc03235a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Enantiomeric carbon dots (C-dots) synthesized froml -lysine ord -lysine, modulate aggregation and cytotoxicity of amyloid beta-42 (Aβ42), the primary constituent of the amyloid plaques associated with Alzheimer's disease. Abstract : Enantiomeric carbon dots (C-dots) synthesized froml -lysine ord -lysine, modulate aggregation and cytotoxicity of amyloid beta-42 (Aβ42), the primary constituent of the amyloid plaques associated with Alzheimer's disease. In particular, l -Lys-C-dots dramatically remodeled Aβ42 secondary structure and fibril morphologies, as well as inhibited Aβ42 cytotoxicity and membrane interactions.