2, 3-Dihydroquinazolin-4(1H)-one as a privileged scaffold in drug design. Issue 37 (7th June 2018)

• Record Type: Journal Article
• Authors: Badolato, Mariateresa; Aiello, Francesca; Neamati, Nouri
• Is Part Of: RSC advances. Volume 8:Issue 37(2018)
• Page Start: 20894
• Page End: 20921
• Publication Date: 2018-06-07
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra02827c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : 2, 3-Dihydroquinazolin-4-one (DHQ) belongs to the class of nitrogen-containing heterocyclic compounds representing a core structural component in various biologically active compounds. Abstract : 2, 3-Dihydroquinazolin-4-one (DHQ) belongs to the class of nitrogen-containing heterocyclic compounds representing a core structural component in various biologically active compounds. In the past decades, several methodologies have been developed for the synthesis of the DHQ framework, especially the 2-substituted derivatives. Unfortunately, multistep syntheses, harsh reaction conditions, and the use of toxic reagents and solvents have limited their full potential as a versatile fragment. Recently, use of green chemistry and alternative strategies are being explored to prepare diverse DHQ derivatives. This fragment is used as a synthon for the preparation of biologically active quinazolinones and as a functional substrate for the synthesis of modified DHQ derivatives exhibiting different biological properties. In this review, we provide a comprehensive assessment of the synthesis and biological evaluations of DHQ derivatives.