Antibacterial quaternary ammonium compounds in dental materials: A systematic review. Issue 6 (June 2018)

• Record Type: Journal Article
• Authors: Makvandi, Pooyan; Jamaledin, Rezvan; Jabbari, Mostafa; Nikfarjam, Nasser; Borzacchiello, Assunta
• Is Part Of: Dental materials. Volume 34:Issue 6(2018)
• Page Start: 851
• Page End: 867
• Publication Date: 2018-06
• Subjects: BEMA 2-bromoethyl methacrylate -- HEMA 2-hydroxyethylmethacrylate -- MAE-HB 2-methacryloxylethyl hexadecyl methyl ammonium bromide -- MPS 3-methacryloxypropyltrimethoxysilane -- BC benzyl chloride -- IDMA-1 bis(2-ethacryloyloxyethyl)dimethylammonium bromide -- bis-EMA bisphenol A ethoxylated dimethacrylate -- bis-GMA bisphenol-glycerolate dimethacrylate -- BB butyl bromide -- CFU colony-forming unit -- CSLM confocal laser scanning microscopy -- DC degree of conversion -- DMADDM dimethylaminododecylmethacrylate -- DMAEMA dimethylaminoethyl methacrylate -- DB dodecyl bromide -- SEM electron microscopy -- EDMAB ethyl-4-dimethylaminobenzoate -- HB hexadecyl bromide -- MAE-DB methacryloxylethyl dodecyl methyl ammonium bromide -- MDPB methacryloyloxydodecylpyridinium bromide -- DMAE-BC methacryloxylethyl benzyl dimethyl ammonium chloride -- DMAE-CB methacryloxylethyl cetyl ammonium chloride -- DMAE-m-CBC methacryloxylethyl m-chloro benzyl dimethyl ammonium chloride -- MBC minimum bactericidal concentration -- MIC minimum inhibitory concentrations -- DMAH N, N-dimethylaminohexane -- OTMS octyltrimethoxysilane -- PBS phosphate buffered saline -- OPPI P-octyloxy-phenyl-phenyl iodonium hexafluoroantimonate -- QAM quaternary ammonium monomer -- QABGMA quaternary ammonium bis-phenol A glycerolate dimethacrylate -- QACS quaternary ammonium compounds -- QASs quaternary ammonium salts -- QPEI quaternary ammonium poly(ethylenimine) nanoparticles -- SBM Scotchbond multi-purpose -- SWCNTs single-walled carbon nanotubes -- TEGDMA triethylene glycol dimethacrylate -- TPO trimethylbenzoyl-diphenyl-phosphine oxide -- TPO trimethylbenzoyl-diphenyl-phosphine oxide -- UDMA urethane dimethacrylate -- UDMS urethane dimethacrylate silane -- ZnO-NPs zinc oxide nanoparticles; Antimicrobial -- Dental adhesive -- Nanocomposite -- Restorative dentistry -- Nanofiller -- Surface modification; Dentistry -- Periodicals; Dental materials -- Periodicals; 617.695
• DOI: 10.1016/j.dental.2018.03.014
• Languages: English
• ISSNs: 0109-5641

Abstract

Abstract: Objective: Quaternary ammonium compounds (QACs) represent one of the most effective classes of disinfectant agents in dental materials and resin nanocomposites. This reviews aims to give a wide overview on the research in the field of antibacterial QACs in dental materials and nanocomposites. Method: An introduction to dental materials components as well as the microorganisms and methods of evaluation for the antimicrobial assays are presented. Then, the properties and synthesis route of QACs, as monomer and filler, are shown. Finally, antimicrobial monomers and fillers, specifically those contain quaternary ammonium salts (QASs), in dental materials are reviewed. Results: QACs have been used as monomer and micro/nanofiller in restorative dentistry. They possess one or more methacrylate functional groups to participate in polymerization reactions. QACs with multiple methacrylate groups can also be used as crosslinking agents. Furthermore, QACs with chain length from ∼12 to 16 have higher antimicrobial activity in cured dental resins. In general, increasing the chain length leads to a threshold value (critical point) and then it causes decrease in the antimicrobial activity. Significance: The current state of the art of dental materials and resin nanocomposites includes a wide variety of antimicrobial materials. Among them, QACs presents low cytotoxicity and excellent long-term antimicrobial activity without leaching out over time.