Neuroinflammatory and morphological changes in late-life depression: the NIMROD study. (December 2016)

• Record Type: Journal Article
• Authors: Su, Li; Faluyi, Yetunde O.; Hong, Young T.; Fryer, Tim D.; Mak, Elijah; Gabel, Silvy; Hayes, Lawrence; Soteriades, Soteris; Williams, Guy B.; Arnold, Robert; Passamonti, Luca; Rodríguez, Patricia Vázquez; Surendranathan, Ajenthan; Bevan-Jones, Richard W.; Coles, Jonathan; Aigbirhio, Franklin; Rowe, James B.; O'Brien, John T.
• Is Part Of: British journal of psychiatry. Volume 209:Number 6(2016)
• Page Start: 525
• Page End: 526
• Publication Date: 2016-12
• Subjects: Psychiatry -- Periodicals; Psychology, Pathological -- Periodicals; 616.89005
• DOI: 10.1192/bjp.bp.116.190165
• Languages: English
• ISSNs: 0007-1250

Abstract

Summary: We studied neuroinflammation in individuals with late-life, depression, as a risk factor for dementia, using [ 11 C]PK11195 positron emission tomography (PET). Five older participants with major depression and 13 controls underwent PET and multimodal 3T magnetic resonance imaging (MRI), with blood taken to measure C-reactive protein (CRP). We found significantly higher CRP levels in those with late-life depression and raised [ 11 C]PK11195 binding compared with controls in brain regions associated with depression, including subgenual anterior cingulate cortex, and significant hippocampal subfield atrophy in cornu ammonis 1 and subiculum. Our findings suggest neuroinflammation requires further investigation in late-life depression, both as a possible aetiological factor and a potential therapeutic target.