Iodine promoted iodosulfonylation of alkynes with sulfonyl hydrazides in an aqueous medium: highly stereoselective synthesis of (E)-β-iodo vinylsulfones. (26th April 2018)

• Record Type: Journal Article
• Authors: Hou, Yunlei; Zhu, Liangyu; Hu, Hao; Chen, Shaowei; Li, Zefei; Liu, Yajing; Gong, Ping
• Is Part Of: New journal of chemistry. Volume 42:Number 11(2018)
• Page Start: 8752
• Page End: 8755
• Publication Date: 2018-04-26
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c8nj01145a
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : An efficient, molecular iodine-promoted MCR of alkynes and sulfonyl hydrazide for the synthesis of ( E )-β-iodo vinylsulfone derivatives has been developed. Abstract : A catalyst-free and metal-free sulfonylation reaction for the preparation of ( E )-β-iodo vinylsulfones from alkynes with sulfonyl hydrazides and molecular iodine was efficiently developed under mild and environmentally benign conditions, in water without any ligand or catalyst. The reaction gave a range of structurally diverse β-iodo vinylsulfones with excellent E selectivities and high yields.