Application of chiral bi- and tetra-dentate bispidine-derived ligands in the copper(ii)-catalyzed asymmetric Henry reaction. (22nd June 2018)

• Record Type: Journal Article
• Authors: Rossetti, Arianna; Landoni, Stefano; Meneghetti, Fiorella; Castellano, Carlo; Mori, Matteo; Colombo Dugoni, Greta; Sacchetti, Alessandro
• Is Part Of: New journal of chemistry. Volume 42:Number 14(2018)
• Page Start: 12072
• Page End: 12081
• Publication Date: 2018-06-22
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c8nj01930d
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Rationalized bispidinone-based ligands were reacted with copper(ii ) salts, which afforded effective catalysts for asymmetric Henry reactions. Abstract : The application of a number of chiral bispidine-based ligands in the copper-catalyzed enantioselective Henry reaction is here reported. The results showed good conversion rates and low to moderate enantiomeric ratios, depending on the substituents on the bispidine core. The enantioselectivities of selected ligands were rationalized on the basis of single-crystal X-ray analyses, NMR studies and computational tools.