Increased mortality among people with anxiety disorders: total population study. (September 2016)

• Record Type: Journal Article
• Authors: Meier, Sandra M.; Mattheisen, Manuel; Mors, Ole; Mortensen, Preben B.; Laursen, Thomas M.; Penninx, Brenda W.
• Is Part Of: British journal of psychiatry. Volume 209:Number 3(2016)
• Page Start: 216
• Page End: 221
• Publication Date: 2016-09
• Subjects: Psychiatry -- Periodicals; Psychology, Pathological -- Periodicals; 616.89005
• DOI: 10.1192/bjp.bp.115.171975
• Languages: English
• ISSNs: 0007-1250

Abstract

Abstract : Background: Anxiety disorders and depression are the most common mental disorders worldwide and have a striking impact on global disease burden. Although depression has consistently been found to increase mortality; the role of anxiety disorders in predicting mortality risk is unclear. Aims: To assess mortality risk in people with anxiety disorders. Method: We used nationwide Danish register data to conduct a prospective cohort study with over 30 million person-years of follow-up. Results: In total, 1066 (2.1%) people with anxiety disorders died during an average follow-up of 9.7 years. The risk of death by natural and unnatural causes was significantly higher among individuals with anxiety disorders (natural mortality rate ratio (MRR) = 1.39, 95% CI 1.28–1.51; unnatural MRR= 2.46, 95% CI 2.20–2.73) compared with the general population. Of those who died from unnatural causes, 16.5% had comorbid diagnoses of depression (MRR = 11.72, 95% CI 10.11–13.51). Conclusions: Anxiety disorders significantly increased mortality risk. Comorbidity of anxiety disorders and depression played an important part in the increased mortality.