A perylene diimide zwitterionic polymer for photoacoustic imaging guided photothermal/photodynamic synergistic therapy with single near-infrared irradiation. Issue 20 (16th May 2018)

• Record Type: Journal Article
• Authors: Sun, Pengfei; Wang, Xiaoxiao; Wang, Gaina; Deng, Weixing; Shen, Qingming; Jiang, Rongcui; Wang, Wenjun; Fan, Quli; Huang, Wei
• Is Part Of: Journal of materials chemistry. Volume 6:Issue 20(2018)
• Page Start: 3395
• Page End: 3403
• Publication Date: 2018-05-16
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c8tb00845k
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A biocompatible zwitterionic polymer (PDS-PDI) was designed for PAI guided synergistic PDT and PTT with single NIR light irradiation. Abstract : Phototherapy has great promise for precise cancer diagnosis and effective therapy, but the development of one multifunctional nanoplatform for synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) at a single excitation wavelength remains a challenge. In this work, a perylene diimide zwitterionic polymer PDS-PDI was synthesized via atom transfer radical polymerization (ATRP). This polymer was designed for photoacoustic imaging (PAI) guided synergistic PDT and PTT with single 660 nm near-infrared (NIR) light irradiation. The prepared PDS-PDI polymer presents high photothermal conversion efficiency ( η ≈ 40%) and efficient singlet oxygen quantum yield ( Φ Δ ≈ 16.7%) under 660 nm laser irradiation. Polymer PDS-PDI also acts as a contrast agent for PAI, offering real-time monitoring in tumor sites. Additionally, in vitro and in vivo assays indicate that polymer PDS-PDI has good biocompatibility and effective tumor destruction ability under 660 nm laser irradiation. In brief, polymer PDS-PDI prepared in this study could be applied as a dual-mode phototherapeutic agent under single laser irradiation.