Anti-staphylococcal biofilm activity of miconazoctylium bromide. Issue 23 (25th May 2018)

• Record Type: Journal Article
• Authors: Tessier, Jérémie; Golmohamadi, Mahmood; Wilkinson, Kevin J.; Schmitzer, Andreea R.
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 23(2018)
• Page Start: 4288
• Page End: 4294
• Publication Date: 2018-05-25
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob00897c
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Alkylmiconazolium salts possess a high potency to disrupt bacterial biofilms. Abstract : We designed and synthesized miconazole analogues containing a substituted imidazolium moiety. The structural modification of the miconazole led to a compound with high potency to prevent the formation and disrupt bacterial biofilms, as a result of accumulation in the biofilm matrix, permeabilization of the bacterial membrane and generation of reactive oxygen species in the cytoplasm.