Antibacterial coordination polymer hydrogels composed of silver(i)-PEGylated bisimidazolylbenzyl alcohol. Issue 37 (6th June 2018)

• Record Type: Journal Article
• Authors: Wu, Fang; He, Dengfeng; Chen, Lei; Liu, Fangqin; Huang, Haolong; Dai, Jiangshan; Zhang, Shiyong; You, Jingsong
• Is Part Of: RSC advances. Volume 8:Issue 37(2018)
• Page Start: 20829
• Page End: 20835
• Publication Date: 2018-06-06
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra00682b
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Herein, antibacterial coordination polymer hydrogels were conveniently fabricated in water via coordination between silver nitrate and PEGylated bisimidazolylbenzyl alcohol (1a–c ). Abstract : Herein, antibacterial coordination polymer hydrogels were conveniently fabricated in water via coordination between silver nitrate and PEGylated bisimidazolylbenzyl alcohol (1a–c ). These coordination polymer hydrogels exhibit much better antibacterial activity than silver nitrate against both Gram-negative and Gram-positive pathogens including multidrug-resistant pathogens. The coordination polymerAg/1c with a long PEG chain (PEG1000) was demonstrated to be the most effective antibacterial material, and its minimum inhibition concentrations (MICs) could be as low as 15.2 times for common Staphylococcus aureus and 4.8 times for methicillin-resistant Staphylococcus aureus over that of silver nitrate. With improved antibacterial performance, easy preparation method, improved stability, sustained releasability, outstanding ductility and low cytotoxicity, the as-prepared coordination polymer hydrogels should find various potential applications such as in clinical burn and wound dressings, biofilms, bioadhesives, and coatings of biomedical materials.