Monascus pigment rubropunctatin derivative FZU-H reduces Aβ(1-42)-induced neurotoxicity in Neuro-2A cells. Issue 31 (14th May 2018)

• Record Type: Journal Article
• Authors: Zheng, Yunquan; Pan, Qisheng; Mo, Liuda; Zhang, Wenyi; Duan, Yunjian; Chen, Chengqun; Chen, Haijun; Guo, Yanghao; Shi, Xianai; Yang, Jianmin
• Is Part Of: RSC advances. Volume 8:Issue 31(2018)
• Page Start: 17389
• Page End: 17398
• Publication Date: 2018-05-14
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra02365d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Monascus pigment rubropunctatin derivative FZU-H shows promising neuroprotective effects for AD. Abstract : Alzheimer's disease (AD) is an extremely complex disease, characterized by several pathological features including oxidative stress and amyloid-β (Aβ) aggregation. Blockage of Aβ-induced injury has emerged as a potential therapeutic approach for AD. Our previous efforts resulted in the discovery of Monascus pigment rubropunctatin derivative FZU-H with potential neuroprotective effects. This novel lead compound significantly diminishes toxicity induced by Aβ(1-42) in Neuro-2A cells. Our further mechanism investigation revealed that FZU-H inhibited Aβ(1-42)-induced caspase-3 protein activation and the loss of mitochondrial membrane potential. In addition, treatment of FZU-H was proven to attenuate Aβ(1-42)-induced cell redox imbalance and Tau hyperphosphorylation which caused by okadaic acid in Neuro-2A cells. These results indicated that FZU-H shows promising neuroprotective effects for AD.