Design, synthesis and biological evaluation of N-arylsulfonyl carbazoles as novel anticancer agents. Issue 31 (10th May 2018)

• Record Type: Journal Article
• Authors: You, Xin; Zhu, Daqian; Lu, Wenhua; Sun, Yichen; Qiao, Shuang; Luo, Bingling; Du, Yongliang; Pi, Rongbiao; Hu, Yumin; Huang, Peng; Wen, Shijun
• Is Part Of: RSC advances. Volume 8:Issue 31(2018)
• Page Start: 17183
• Page End: 17190
• Publication Date: 2018-05-10
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra02939c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : In this work, a set of structurally diverse synthetic carbazoles was screened for their anticancer activities. Abstract : In this work, a set of structurally diverse synthetic carbazoles was screened for their anticancer activities. According to structure–activity relationship studies, carbazoles with an N -substituted sulfonyl group exhibited better anticancer activity. Moreover, compound8h was discovered to show the most potent anticancer effects on Capan-2 cells by inducing apoptosis and cell cycle arrest in G2/M phase. Finally, the in vivo study demonstrated that8h prevented the tumor growth in PANC-1 and Capan-2 xenograft models without apparent toxicity.