Utilisation of real-world data from heart failure registries in OECD countries - A systematic review. (June 2018)

• Record Type: Journal Article
• Authors: Du, Xiaoyang; Khamitova, Adina; Kyhlstedt, Mattias; Sun, Sun; Sengoelge, Mathilde
• Is Part Of: IJC heart & vasculature. Volume 19(2018)
• Page Start: 90
• Page End: 97
• Publication Date: 2018-06
• Subjects: CONSORT consolidated standards of reporting trials -- HF heart failure -- OECD Organisation for Economic Co-operation and Development -- PRISMA Preferred Reporting Items for Systematic Review and Meta-Analysis -- PROMS patient reported outcome measures -- RCT randomised controlled trial -- RRCT registry-based randomised clinical trials -- RWD real-world data; Systematic review -- Heart failure -- Registry -- Real-world data -- Observational study -- OECD; Cardiovascular system -- Diseases -- Periodicals; Cardiovascular system -- Pathophysiology -- Periodicals; 616.1005
• DOI: 10.1016/j.ijcha.2018.02.006
• Languages: English
• ISSNs: 2352-9067

Abstract

Abstract: Background: Heart failure represents a major public health issue that impacts 26 million people globally. Currently, real-world data represents a key instrument for providing the verification of both internal and external validity, yet there is still a lack of understanding regarding its scope in complementing evidence of treatments for heart failure. This study aims to increase understanding of the utilisation of real-word data from heart failure registries in Organisation for Economic Co-operation and Development (OECD) countries. Method: This was a systematic review of existing observational studies from heart failure registries in 35 OECD member countries. Studies from 2000 to March 2017 were identified through electronic databases (MEDLINE (Ovid), EMBASE, Web of Science Core Collection, CINAHL (Ebsco), Cochrane CENTRAL) and appraised according to eligibility criteria. Results: Two-hundred and two studies met the inclusion criteria, in which the majority were published from 2013 to 2016. All 202 studies were observational, among which 98% were cohort studies (198). The median sample size of all studies was 5152 (2417 to 32, 890) and median study period 55 months (33.0 to 72.0). Swedish heart failure registry had the most publications (24, 12%). Conclusion: Since 2000 there has been an upward trend in the number of published observational studies on heart failure registries in OECD countries with increasingly diverse outcomes and advanced statistical methods to improve their validity and reliability. This indicates that the utilisation of real-world data has experienced a significant upsurge in complementing the findings of clinical trials for improved research of heart failure treatments. Highlights: The utilisation of real-world data from heart failure registries has been gradually increasing since the 2000s Survival, length of inpatient stay, and cost were defined as outcomes, complementing research of heart failure treatments. An assessment of the quality of the published studies based on RWD would be needed in future research.