Patterns of disease progression in patients with local and metastatic breast cancer as evaluated by whole-body magnetic resonance imaging. (August 2018)

• Record Type: Journal Article
• Authors: Kosmin, Michael; Padhani, Anwar R.; Sokhi, Heminder; Thijssen, Toon; Makris, Andreas
• Is Part Of: Breast. Volume 40(2018)
• Page Start: 82
• Page End: 84
• Publication Date: 2018-08
• Subjects: Whole-body MRI -- Metastatic breast cancer -- Response assessment; Breast -- Diseases -- Periodicals; Breast -- Tumors -- Periodicals; Breast -- Periodicals; Electronic journals; Periodicals; 616
• DOI: 10.1016/j.breast.2018.04.019
• Languages: English
• ISSNs: 0960-9776

Abstract

Abstract: Background: Patterns of progressive disease (PD) in patients with local and metastatic sites of breast cancer are poorly described. Whole-body magnetic resonance imaging (WB-MRI) identifies PD earlier than CT. Methods: Thirty-one patients receiving first-line systemic anti-cancer therapy (SACT) were studied. Data were obtained from original WB-MRI reports. Results: First PD was reported at metastatic sites only in 77.4%, and at local and metastatic sites concurrently in 22.6%. None had first PD only in local disease, or clinical PD before PD on WB-MRI. Conclusion: Clinical evidence of SACT benefit in local disease may give false reassurance about disease at metastatic sites. Highlights: Most patients with local & metastatic breast cancer progress first at distant sites. SACT benefit in local disease is not always linked to benefit at metastatic sites. Regular clinical review and imaging reassessment are advised.