Increased blood BDNF in healthy individuals with a family history of depression. (October 2017)

• Record Type: Journal Article
• Authors: Knorr, Ulla; Søndergaard, Mia H. Greisen; Koefoed, Pernille; Jørgensen, Anders; Faurholt-Jepsen, Maria; Vinberg, Maj; Kessing, Lars Vedel
• Is Part Of: Psychiatry research. Volume 256(2017)
• Page Start: 176
• Page End: 179
• Publication Date: 2017-10
• Subjects: Psychiatry -- Periodicals; Psychiatry -- periodicals; Psychiatrie -- Périodiques; 616.89
• DOI: 10.1016/j.psychres.2017.06.057
• Languages: English
• ISSNs: 0165-1781

Abstract

Abstract: The brain-derive neurotrophic factor (BDNF) may play an important role in the course of depression. We aimed to study the associations between peripheral whole blood BDNF levels in healthy individuals with and without a family history of depression. BDNF levels were significantly increased in healthy individuals with ( n = 76 ), compared with healthy individuals without ( n = 39 ) a family history of depression and persisted after adjustment for age and gender differences. Higher BDNF levels were associated with increasing age and seasonality. A family history of depression may contribute to an elevation of peripheral BDNF levels in healthy individuals. Highlights: In this case-control study we aimed at investigating BDNF levels in peripheral blood in healthy individuals with or without a family history of depression. Blood BDNF protein concentrations were significantly higher in the individuals with a family history of depression. Seasonality is important to consider i future studies of BDNF. We investigated peripheral BDNF in healthy with and without a family history of depression.