Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists. Issue 15 (1st August 2017)

• Record Type: Journal Article
• Authors: Zhang, Xuqing; Cai, Chaozhong; Winters, Michael; Wells, Michele; Wall, Mark; Lanter, James; Sui, Zhihua; Ma, Jingyuan; Novack, Aaron; Nashashibi, Imad; Wang, Yuanping; Yan, Wen; Suckow, Arthur; Hua, Hong; Bell, Austin; Haug, Peter; Clapper, Wilma; Jenkinson, Celia; Gunnet, Joseph; Leonard, James; Murray, William V.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 27:Issue 15(2017)
• Page Start: 3272
• Page End: 3278
• Publication Date: 2017-08-01
• Subjects: GPR120 -- Type 2 diabetes -- Phenylpropanoic acid; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2017.06.028
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: A novel series of 5-membered heterocycle-containing phenylpropanoic acid derivatives (I ) was discovered as potent GPR120 agonists with low clearance, high oral bioavailability and in vivo antidiabetic activity in rodents. Abstract: A novel series of 5-membered heterocycle-containing phenylpropanoic acid derivatives was discovered as potent GPR120 agonists with low clearance, high oral bioavailability and in vivo antidiabetic activity in rodents.