Efficacy of web-based cognitive–behavioural therapy for chronic fatigue syndrome: randomised controlled trial. (1st February 2018)

• Record Type: Journal Article
• Authors: Janse, A.; Worm-Smeitink, M.; Bleijenberg, G.; Donders, R.; Knoop, H.
• Is Part Of: British journal of psychiatry. Volume 212:Number 2(2018)
• Page Start: 112
• Page End: 118
• Publication Date: 2018-02-01
• Subjects: Psychiatry -- Periodicals; Psychology, Pathological -- Periodicals; 616.89005
• DOI: 10.1192/bjp.2017.22
• Languages: English
• ISSNs: 0007-1250

Abstract

Abstract : Background: Face-to-face cognitive–behavioural therapy (CBT) leads to a reduction of fatigue in chronic fatigue syndrome (CFS). Aims: To test the efficacy of internet-based CBT (iCBT) for adults with CFS. Method: A total of 240 patients with CFS were randomised to either iCBT with protocol-driven therapist feedback or with therapist feedback on demand, or a waiting list. Primary outcome was fatigue severity assessed with the Checklist Individual Strength (Netherlands Trial Register: NTR4013). Results: Compared with a waiting list, intention-to-treat (ITT) analysis showed a significant reduction of fatigue for both iCBT conditions (protocol-driven feedback: B = −8.3, 97.5% CI −12.7 to −3.9, P < 0.0001; feedback on demand: B = −7.2, 97.5% CI −11.3 to –3.1, P < 0.0001). No significant differences were found between both iCBT conditions on all outcome measures ( P = 0.3–0.9). An exploratory analysis revealed that feedback-on-demand iCBT required less therapist time (mean 4 h 37 min) than iCBT with protocol-driven feedback (mean 6 h 9 min, P < 0.001) and also less than face-to-face CBT as reported in the literature. Conclusions: Both iCBT conditions are efficacious and time efficient. Declaration of interest: None.