Simultaneous involvement of 11q23 translocation resulting in chimeric MLL-AFF1 and a second translocation [t (9;21) (p13; p11.2)] in an infant acute lymphoblastic leukemia patient at relapse: A case report. Issue 21 (May 2018)

• Record Type: Journal Article
• Authors: Liu, Guangming; Lu, Xianglan; Kim, Young Mi; Wang, Xianfu; Li, Shibo; Liu, Yuanyuan
• Other Names: NA. section editor.
• Is Part Of: Medicine. Volume 97:Issue 21(2018)
• Publication Date: 2018-05
• Subjects: FISH -- infant ALL -- MLL-AFF1 -- t (4 ;11 ;11) -- t (9 ;21); Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000010874
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Rationale: Three-way translocations occasionally occur in MLL-AFF1 fusion and other fusion gene. However, the complex chromosomal rearrangements in the study were the first report. Patient concerns: We present novel cryptic and complex chromosomal rearrangements [der (21) t (9; 21) (p13; p11.2)] in an infant patient with relapsed acute lymphoblastic leukemia (ALL). Diagnoses: The diagnosis was based on morphologic, cytochemical, and immunophenotypic criteria proposed by the French-American-British Committee, and karyotype, fluorescence in situ hybridization, array comparative genomic hybridization. Interventions: The patient was given chemotherapy with standard protocol for ALL. Outcomes: The patient had unfavorable prognostic outcome based on the cytogenetic and molecular cytogenetic markers. After short remission, the patient relapsed. Lessons: MLL-AFF1, resulting from t(4;11)(q21;q23), is regarded as the hallmark of infant t(4;11) pre-B/mixed B-ALL. It is associated with a dismal prognosis and the multiple-way translocation involving chromosomes 4, 11 and 11 may function as an enhancer.