Selenium deficiency and pregnancy outcome in pregnant women with HIV in Lagos, Nigeria. Issue 2 (23rd April 2018)

• Record Type: Journal Article
• Authors: Okunade, Kehinde S.; Olowoselu, Olusola F.; Osanyin, Gbemisola E.; John‐Olabode, Sarah; Akanmu, Sulaimon A.; Anorlu, Rose I.
• Is Part Of: International journal of gynaecology and obstetrics. Volume 142:Issue 2(2018)
• Page Start: 207
• Page End: 213
• Publication Date: 2018-04-23
• Subjects: CD4+ cell count -- HIV -- Lagos -- Low delivery weight -- Preterm delivery -- Selenium -- Viral load; Gynecology -- Periodicals; Obstetrics -- Periodicals; Electronic journals; 618
• DOI: 10.1002/ijgo.12508
• Languages: English
• ISSNs: 0020-7292

Abstract

Abstract: Objective: To investigate the prevalence of maternal selenium deficiency and its effects on pregnancy outcomes in pregnant women with HIV in Lagos, Nigeria. Methods: The present descriptive cross‐sectional study enrolled women aged 15–49 years with HIV who were at 14–26 weeks of a singleton pregnancy and were attending Lagos University Teaching Hospital, Lagos, Nigeria, between August 1, 2016, and April 30, 2017. Participants were selected by consecutive sampling and baseline data were collected through interviews. Venous blood samples were obtained to measure selenium concentrations, and associations between low maternal selenium concentrations (defined as <0.89 μmol/L) and pregnancy outcomes were examined using bivariate and multivariate analysis. Results: The final analysis included 113 patients; selenium deficiency was recorded in 23 (20.4%) patients. Women with selenium deficiency had an approximately eight‐fold higher risk of preterm delivery (adjusted odds ratio 7.61, 95% confidence interval 4.37–18.89; P =0.031) and of delivering a term neonate with a low delivery weight (adjusted odds ratio 8.11, 95% confidence interval 3.27–17.22; P =0.012), compared with women with a normal selenium concentration. Conclusion: The prevalence of selenium deficiency among pregnant women with HIV in Lagos was relatively high. The significant associations observed between maternal selenium deficiency and adverse pregnancy outcomes could have implications for the future management of HIV in pregnancy. Abstract : The prevalence of selenium deficiency among HIV‐positive pregnant women in Nigeria was high, and the maternal selenium status was significantly associated with pregnancy outcomes.