Cross‐Linked Sodium Alginate‐g‐poly(Acrylic Acid) Structure: A Potential Hydrogel Network for Controlled Delivery of Loxoprofen Sodium. Issue 4 (2nd August 2016)

• Record Type: Journal Article
• Authors: Khalid, Ikrima; Ahmad, Mahmood; Usman Minhas, Muhammad; Barkat, Kashif; Sohail, Muhammad
• Is Part Of: Advances in polymer technology. Volume 37:Issue 4(2018)
• Page Start: 985
• Page End: 995
• Publication Date: 2016-08-02
• Subjects: Acrylic acid -- Hydrogel -- Loxoprofen sodium hydrate -- pH‐responsive -- Sodium alginate; Plastics -- Periodicals; Polymers -- Periodicals; 668.9
• DOI: 10.1002/adv.21747
• Languages: English
• ISSNs: 0730-6679

Abstract

Abstract: A series of sodium alginate‐graft‐poly(acrylic acid) hydrogels (SA‐g‐pAA hydrogels) were synthesized with sodium alginate (SA) and acrylic acid (AA) in aqueous solution, ethylene glycol dimethacrylate (EGDMA) as a cross‐linker and ammonium peroxodisulfate (APS) as an initiator. Hydrogels were evaluated for thermal stability (TGA & DSC), revealing their higher strength toward thermal variation as compared to individual components. SEM micrographs show smooth and solid outer surface with a lack of porosity on it. FTIR results revealed the grafting reaction of AA on SA. Hydrogels were then evaluated for pH responsive behavior by equilibrium swelling ratio and swelling dynamics at low and high pH. Furthermore, these cross‐linked networks were also tested for the release of Loxoprofen sodium hydrate (LSH). Drug was loaded by diffusion method and showed pH‐dependent drug release characteristics. Korsmeyer–Peppas model is the best fit model to explain drug release from the cross‐linked network. Maximum swelling, drug loading, and release has been observed at pH 7.4. It is concluded that highly stable SA and AA based polymeric matrixes are developed. These polymeric matrixes have potential to be used as a carrier for controlled delivery of LSH.