Definitive re-irradiation using intensity-modulated radiation therapy in cancers of the head and neck, focusing on rare tumors. (3rd August 2018)

• Record Type: Journal Article
• Authors: Doi, Hiroshi; Uemoto, Kenji; Masai, Norihisa; Tatsumi, Daisaku; Shiomi, Hiroya; Oh, Ryoong-Jin
• Is Part Of: Acta oto-laryngologica. Volume 138:Number 8(2018)
• Page Start: 750
• Page End: 758
• Publication Date: 2018-08-03
• Subjects: Intensity-modulated radiation therapy -- re-irradiation -- paranasal sinus carcinoma -- maxillary sinus carcinoma -- radiotherapy -- head and neck -- stereotactic body radiation therapy; Otolaryngology -- Periodicals; Ear -- Diseases -- Periodicals; Throat -- Diseases -- Periodicals; Otolaryngology -- Electronic Resources; Otorhinolaryngologic Diseases; 617.8
• DOI: 10.1080/00016489.2018.1438662
• Languages: English
• ISSNs: 0001-6489

Abstract

Abstract: Purpose: To analyze the outcomes following re-irradiation for local recurrence of rare head and neck tumors. Material and methods: We retrospectively analyzed 11 patients who had received intensity-modulated radiation therapy (IMRT) for recurrent tumors in the head and neck except for laryngopharynx. Results: Primary tumor sites included the maxillary sinus, nasal cavity, and external ear canal in six, three, and two patients, respectively. The median follow-up times were 13 (range, 3–54) months. The median survival time was 17 months with 1- and 2-year survival rates of 63.64 and 39.77%, respectively. Among 11 patients, five experienced local failure in the follow-up period. The 1- and 2-year local control rates were 58 and 47%, respectively. Patients who had received a radiation dose of ≥3 Gy per fraction showed significantly better local control than those receiving less ( p = .0419). One patient experienced Grade 3 facial pain as acute toxicity. Late toxicities included radiographic findings of partial central nervous system necrosis in three patients and Grade 3 osteonecrosis and Grade 3 facial nerve disorder in one patient. Conclusions: Re-irradiation of rare head and neck tumors using IMRT for loco-regional recurrence may be an acceptable treatment option.