Association of pulse wave velocity with single nucleotide polymorphisms related to parathyroid hormone. (4th July 2018)

• Record Type: Journal Article
• Authors: Cheng, Yi-Bang; Guo, Qian-Hui; Zhang, Dong-Yan; Wang, Ying; Huang, Qi-Fang; Sheng, Chang-Sheng; Wang, Ji-Guang; Staessen, Jan A.; Li, Yan
• Is Part Of: Blood pressure. Volume 27:Number 4(2018)
• Page Start: 222
• Page End: 230
• Publication Date: 2018-07-04
• Subjects: Arterial stiffness -- blood pressure -- clinical genetics -- parathyroid hormone -- pulse wave velocity; Blood pressure -- Periodicals; Hypertension -- Periodicals; Hypertension -- Periodicals; Blood Pressure -- Periodicals; 612.14
• DOI: 10.1080/08037051.2018.1445961
• Languages: English
• ISSNs: 0803-7051

Abstract

Abstract: Objective: Carotid-femoral pulse wave velocity (cfPWV) was associated with serum parathyroid hormone (PTH) in untreated Chinese. We investigated in the same cohort whether cfPWV, brachial-ankle (baPWV) and heart-brachial (hbPWV) pulse wave velocity (PWV) were associated with rs6127099 ( CYP24A1 ) and rs4074995 ( RGS14 ). A previously published genome-wide association study demonstrated that each additional copy of the T (rs6127099) or G (rs4074995) allele was associated with a 7% or 3% higher serum PTH, respectively. Methods: In 1601 untreated Chinese patients (mean age, 51.0 years; 51.9% women), we measured cfPWV by tonometry (SphygmoCor) and baPWV and hbPWV by combined oscillometry and plethysmography (VP-2000 PWV/ABI analyser), serum PTH by an immunoassay, and genotypes by the SNapShot method. Results: cfPWV, baPWV and hbPWV averaged 7.9, 14.6 and 5.5 m/s and serum PTH 65.7 pg/mL. Genotype frequencies were in Hardy-Weinberg equilibrium, amounting to 41.7% ( AA ), 44.9% ( AT ) and 13.4% ( TT) for rs6127099 and to 70.7% ( GG ), 26.9% ( GA ) and 2.3% ( AA ) for rs4074995. With adjustments applied for sex, age, body mass index, heart rate and season, hbPWV was 0.05 m/s ( p = .042) lower with each additional copy of the minor allele ( T ) of rs6127099. In similarly adjusted analyses of 157 normotensive participants younger than 50 years, cfPWV was 0.32 m/s ( p = .004) higher per additional copy of the T allele. Sensitivity analyses additionally accounting for the total-to-HDL serum cholesterol ratio, plasma glucose, glomerular filtration rate and 24 h systolic blood pressure were consistent. No other association of PWV with the genetic variants reached significance. Conclusions: With an increasing number of rs6127099 T alleles, arterial stiffness, as exemplified by PWV, was lower in all participants in a muscular artery (hbPWV), but higher in young normotensive participants in an elastic artery (cfPWV).