A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy. Issue 4 (14th June 2018)

• Record Type: Journal Article
• Authors: Li, Wenjun; Wang, Dongyuan; Shi, Xiaodong; Li, Jingxu; Ma, Yue; Wang, Yanding; Li, Tingting; Zhang, Jianing; Zhao, Rongtong; Yu, Zhiqiang; Yin, Feng; Li, Zigang
• Is Part Of: Materials horizons. Volume 5:Issue 4(2018)
• Page Start: 745
• Page End: 752
• Publication Date: 2018-06-14
• Subjects: Materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c8mh00392k
• Languages: English
• ISSNs: 2051-6347

Abstract

Abstract : Herein, we report a unique siRNA-induced peptide co-assembly nanocarrier, which could efficiently co-assemble upon the addition of siRNA, forming nanospheres with high biocompatibility and transfection efficiency both in vitro and in vivo . Abstract : Herein, we report a unique siRNA-induced peptide co-assembly nanocarrier, which could efficiently co-assemble upon the addition of siRNA, forming nanospheres with high biocompatibility and transfection efficiency both in vitro and in vivo . In a tumor xenograft nude mouse model, these siRNA–peptide nanospheres inhibited tumor volume growth by >60%.