Dopamine signalling in locusts and other insects. (June 2018)

• Record Type: Journal Article
• Authors: Verlinden, Heleen
• Is Part Of: Insect biochemistry and molecular biology. Volume 97(2018)
• Page Start: 40
• Page End: 52
• Publication Date: 2018-06
• Subjects: Behaviour -- Biogenic amine -- Drug -- G protein-coupled receptor -- Insecticide -- Learning and memory -- Locust -- Phase transition; Insect biochemistry -- Periodicals; Insects -- Physiology -- Periodicals; Insects -- Molecular aspects -- Periodicals; Biochemistry -- Periodicals; Insectes -- Biochimie -- Périodiques; Insectes -- Composition -- Périodiques; Insectes -- Physiologie -- Périodiques; Insectes -- Aspect moléculaire -- Périodiques; Biochimie -- Périodiques; Biochemistry; Insect biochemistry; Insects -- Molecular aspects; Insects -- Physiology; Periodicals; 572.8157
• DOI: 10.1016/j.ibmb.2018.04.005
• Languages: English
• ISSNs: 0965-1748

Abstract

Abstract: Dopamine is an important catecholamine neurotransmitter in invertebrates and vertebrates. It is biochemically derived from tyrosine via L-DOPA. It is most abundant in the central nervous system, but can also be produced in e.g. epidermal cells. Dopamine has conserved roles in the control of movement, pleasure, motivation, arousal and memory between invertebrate and vertebrate animals. It is crucial for melanisation and sclerotisation, important processes for the formation of the exoskeleton of insects and immune function. In this brief review I will discuss some general aspects of insect dopamine biosynthesis and breakdown, dopamine receptors and their pharmacology. In addition, I will provide a glance on the multitude of biological functions of dopamine in insects. More detail is provided concerning the putative roles of dopamine in phase related phenomena in locusts. Finally, molecular and pharmacological adjustments of insect dopamine signalling are discussed in the light of possible approaches towards insect pest management. Graphical abstract: Highlights: A comprehensive review concerning all aspects of dopamine-signalling in insects. Classification of insect dopamine receptors and an overview of agonists and antagonists. Potential of the dopamine signalling system for pest management.