Asymmetric total synthesis of (+)-ovafolinins A and B. Issue 54 (26th June 2018)

• Record Type: Journal Article
• Authors: Fang, Xianhe; Shen, Lei; Hu, Xiangdong
• Is Part Of: Chemical communications. Volume 54:Issue 54(2018)
• Page Start: 7539
• Page End: 7541
• Publication Date: 2018-06-26
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc03456g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Benefiting from a highly diastereoselective alkylation of ( S )-Taniguchi lactone, a double Friedel–Crafts reaction, a global debenzylation and a Cu(OAc)2 -enabled benzylic oxidative cyclization, an efficient synthetic approach to (+)-ovafolinins A and B has been developed. Abstract : (+)-Ovafolinins A and B are two homologous lignans containing unique polycyclic skeletons. Benefiting from a highly diastereoselective alkylation of ( S )-Taniguchi lactone, a double Friedel–Crafts reaction, a global debenzylation and a Cu(OAc)2 -enabled benzylic oxidative cyclization, we present herein an efficient synthetic approach to (+)-ovafolinins A and B.