Regioselective deuteration of alcohols in D2O catalysed by homogeneous manganese and iron pincer complexes. Issue 12 (4th June 2018)

• Record Type: Journal Article
• Authors: Kar, Sayan; Goeppert, Alain; Sen, Raktim; Kothandaraman, Jotheeswari; Surya Prakash, G. K.
• Is Part Of: Green chemistry. Volume 20:Issue 12(2018)
• Page Start: 2706
• Page End: 2710
• Publication Date: 2018-06-04
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c8gc01052h
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : Regioselective, base-metal catalyzed deuteration of alcohols in D2 O. Abstract : We report a convenient and cost-effective protocol for the regioselective deuteration of primary and secondary alcohols using Earth abundant homogeneous first row transition metal pincer catalysts. D2 O is utilized as both a deuterium source and a solvent, allowing for a benign inexpensive process. Depending on the metal selected (Mn or Fe), a high degree of deuterium incorporation was observed selectively either at the α and β position (Mn) or exclusively at the α position (Fe), for primary alcohols. This simple, efficient, and cost-effective protocol for alcohol C–H bond deuteration constitutes a powerful tool for the large scale synthesis of deuterated molecules.