A catalyst-controlled switchable reaction of β-keto acids to silyl glyoxylates. Issue 22 (18th May 2018)

• Record Type: Journal Article
• Authors: Han, Man-Yi; Pan, Hong; Lin, Jing; Li, Wei; Li, Pinhua; Wang, Lei
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 22(2018)
• Page Start: 4117
• Page End: 4126
• Publication Date: 2018-05-18
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob00740c
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A catalyst-controlled switchable reaction of β-keto acids to silyl glyoxylates was developed and the decarboxylative-addition products were generated by using a thiourea catalyst. Abstract : A catalyst-controlled switchable reaction of β-keto acids to silyl glyoxylates was developed under mild conditions, providing two distinct products in good yields. Compared to decarboxylative addition-Brook rearrangement, the decarboxylative addition products could be controlled by using a simple bifunctional organocatalyst thiourea derivative instead of DABCO. This new reaction model of silyl glyoxylates offered a facile and alternative route to organosilicon compounds.