Palladium mediated deallylation in fully aqueous conditions for native chemical ligation at aspartic and glutamic acid sites. Issue 22 (16th May 2018)

• Record Type: Journal Article
• Authors: Jbara, Muhammad; Eid, Emad; Brik, Ashraf
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 22(2018)
• Page Start: 4061
• Page End: 4064
• Publication Date: 2018-05-16
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob00890f
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An efficient native chemical ligation approach at Asp and Glu sites is reported applying a hydrazide precursor, as a peptide thioester, and allyl protection at the side chain of Asp and Glu. Abstract : An efficient native chemical ligation approach at Asp and Glu sites is reported applying a hydrazide precursor, as a peptide thioester, and allyl protection at the side chain of Asp and Glu. The allyl protection was efficiently removed, after the ligation step, using the water-soluble palladium complex [Pd(allyl)Cl]2 and glutathione within a few minutes under fully aqueous conditions.