Balancing antimicrobial activity with biological safety: bifunctional chitosan derivative for the repair of wounds with Gram-positive bacterial infections. Issue 23 (29th May 2018)

• Record Type: Journal Article
• Authors: Zhu, Meng; Liu, Peng; Shi, Haigang; Tian, Ye; Ju, Xiaoyan; Jiang, Shidong; Li, Zhuang; Wu, Man; Niu, Zhongwei
• Is Part Of: Journal of materials chemistry. Volume 6:Issue 23(2018)
• Page Start: 3884
• Page End: 3893
• Publication Date: 2018-05-29
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c8tb00620b
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Because of the balance between antimicrobial activity and biological safety, the bifunctional chitosan derivative could control infections and promote healing simultaneously. Abstract : Infection control and the promotion of healing are two key factors during the wound repair process. However, it is still a major challenge for one material to inhibit bacterial growth efficiently and promote wound healing at the same time. Here, a bifunctional chitosan derivative (CS-G/mPEG) was prepared by the successive modification of chitosan with carboxymethoxypolyethylene glycol (mPEG-COOH) and aminoiminomethanesulfonic acid (AIMSOA). We demonstrated that CS-G/mPEG can selectively disrupt bacterial membranes with high efficiency and thus kill Gram-positive bacteria without inducing hemolysis or cytotoxicity. In rats with full-thickness skin wounds infected with Staphylococcus aureus bacteria, CS-G/mPEG inhibited the growth of the bacteria and accelerated the healing of the wounds. Owing to the balance between the antimicrobial activity and biological safety of CS-G/mPEG, this bifunctional chitosan derivative is promising as an ideal anti-infective wound-repairing material for managing wounds with Gram-positive bacterial infections.