Ruthenium-catalyzed C–H allylation of arenes with allylic amines. Issue 21 (14th May 2018)

• Record Type: Journal Article
• Authors: Yan, Rui; Wang, Zhong-Xia
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 21(2018)
• Page Start: 3961
• Page End: 3969
• Publication Date: 2018-05-14
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob00723c
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : The Ru-catalyzed pyridyl-directed C–H allylation of arenes with allylic amines was carried out in the presence of 5 mol% of [Ru( p -cymene)Cl2 ]2 and 0.5 equiv. of AgOAc in CF3 CH2 OH. Abstract : The Ru-catalyzed pyridyl-directed C–H allylation of arenes with allylic amines has been developed. This reaction was carried out in the presence of 5 mol% of [Ru( p -cymene)Cl2 ]2 and 0.5 equiv. of AgOAc in CF3 CH2 OH at 75 °C, affording the allylated products of arenes in moderate to excellent yields. The method exhibits a wide scope of allylic amines and arenes and shows a good compatibility of functional groups. The pyrazolyl- and pyrimidyl-directed C–H allylation of arenes was also performed under the same conditions.