An estrogen receptor targeted ruthenium complex as a two-photon photodynamic therapy agent for breast cancer cells. Issue 51 (6th June 2018)
- Record Type:
- Journal Article
- Title:
- An estrogen receptor targeted ruthenium complex as a two-photon photodynamic therapy agent for breast cancer cells. Issue 51 (6th June 2018)
- Main Title:
- An estrogen receptor targeted ruthenium complex as a two-photon photodynamic therapy agent for breast cancer cells
- Authors:
- Zhao, Xueze
Li, Mingle
Sun, Wen
Fan, Jiangli
Du, Jianjun
Peng, Xiaojun - Abstract:
- Abstract : In this study, we reported a tamoxifen modified Ru(ii ) polypyridyl complex (Ru-tmxf ) as an estrogen receptor (ER) targeted photosensitizer. Abstract : In this study, we reported a tamoxifen modified Ru(ii ) polypyridyl complex (Ru-tmxf ) as an estrogen receptor (ER) targeted photosensitizer.Ru-tmxf displays enhanced cellular uptake and PDT efficiency toward breast cancer cells with high ER expression due to the specific targeting of tamoxifen to ER and finally localizes in lysosomes. Moreover, Ru-tmxf can be activated by two-photon excitation, generating 1 O2 to damage lysosomes and result in cell death.
- Is Part Of:
- Chemical communications. Volume 54:Issue 51(2018)
- Journal:
- Chemical communications
- Issue:
- Volume 54:Issue 51(2018)
- Issue Display:
- Volume 54, Issue 51 (2018)
- Year:
- 2018
- Volume:
- 54
- Issue:
- 51
- Issue Sort Value:
- 2018-0054-0051-0000
- Page Start:
- 7038
- Page End:
- 7041
- Publication Date:
- 2018-06-06
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c8cc03786h ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 6903.xml