Reasons for (non)participation in supplemental population-based MRI breast screening for women with extremely dense breasts. Issue 8 (August 2018)

• Record Type: Journal Article
• Authors: de Lange, S.V.; Bakker, M.F.; Monninkhof, E.M.; Peeters, P.H.M.; de Koekkoek-Doll, P.K.; Mann, R.M.; Rutten, M.J.C.M.; Bisschops, R.H.C.; Veltman, J.; Duvivier, K.M.; Lobbes, M.B.I.; de Koning, H.J.; Karssemeijer, N.; Pijnappel, R.M.; Veldhuis, W.B.; van Gils, C.H.
• Is Part Of: Clinical radiology. Volume 73:Issue 8(2018)
• Page Start: 759.e1
• Page End: 759.e9
• Publication Date: 2018-08
• Subjects: Medical radiology -- Periodicals; Radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiology -- Periodicals; Societies, Medical -- Periodicals; Medical radiology; Radiotherapy; Electronic journals; Periodicals; 616.0757
• DOI: 10.1016/j.crad.2018.04.002
• Languages: English
• ISSNs: 0009-9260

Abstract

Abstract : Aim: To determine the willingness of women with extremely dense breasts to undergo breast cancer screening with magnetic resonance imaging (MRI) in a research setting, and to examine reasons for women to participate or not. Materials and methods: Between 2011 and 2015, 8, 061 women (50–75 years) were invited for supplemental MRI as part of the Dense Tissue and Early Breast Neoplasm Screening (DENSE) trial (ClinicalTrials.gov Identifier: NCT01315015), after a negative screening mammography in the national population-based mammography screening programme. Demographics of participants and non-participants were compared. All invitees were asked to report reasons for (non)participation. Ethical approval was obtained. Participants provided written informed consent. Results: Of the 8, 061 invitees, 66% answered that they were interested, and 59% eventually participated. Participants were on average 54-years old (interquartile range: 51–59 years), comparable to women with extremely dense breasts in the population-based screening programme (55 years). Women with higher socio-economic status (SES) were more often interested in participation than women with lower SES (68% versus 59%, p<0.001). The most frequently stated reasons for non-participation were "MRI-related inconveniences and/or self-reported contraindications to MRI" (27%) and "anxiety regarding the result of supplemental screening" (21%). "Expected personal health benefit" (68%) and "contribution to science" (43%) were the most frequent reasons for participation. Conclusion: Of women invited for MRI because of extremely dense breasts, 59% participated. Common reasons for non-participation were "MRI-related inconveniences" and "anxiety regarding the result of supplemental screening". In case of future implementation, availability of precise evidence on benefits and harms might reduce this anxiety. Highlights: 59% of women with extremely dense breasts participate in supplemental MRI screening. Most common reasons for non-participation were 'MRI-related inconveniences'. Anxiety for the extra screening result was also a common non-participation reason. Addressing this anxiety might improve participation in supplemental screening.