Monte Carlo evaluation of glandular dose in cone-beam X-ray computed tomography dedicated to the breast: Homogeneous and heterogeneous breast models. (July 2018)

• Record Type: Journal Article
• Authors: Sarno, Antonio; Mettivier, Giovanni; Tucciariello, Raffaele M.; Bliznakova, Kristina; Boone, John M.; Sechopoulos, Ioannis; Di Lillo, Francesca; Russo, Paolo
• Is Part Of: Physica medica. Volume 51(2018)
• Page Start: 99
• Page End: 107
• Publication Date: 2018-07
• Subjects: Mean glandular dose -- DgNCT -- Breast CT -- Patient specific digital breast phantoms; Medical physics -- Periodicals; Biophysics -- Periodicals; Biophysics -- Periodicals; Imagerie médicale -- Périodiques; Radiothérapie -- Périodiques; Rayons X -- Sécurité -- Mesures -- Périodiques; Physique -- Périodiques; Médecine -- Périodiques; 610.153
• DOI: 10.1016/j.ejmp.2018.05.021
• Languages: English
• ISSNs: 1120-1797

Abstract

Highlights: Monoenergetic and polyenergetic DgNCT coefficients were computed for homogeneous breast models. 3D digital breast phantoms representing the real breast anatomy were presented. The MGD for homogeneous breast model was 8% higher than that for patient specific phantoms. Abstract: Purpose: In cone-beam computed tomography dedicated to the breast (BCT), the mean glandular dose (MGD) is the dose metric of reference, evaluated from the measured air kerma by means of normalized glandular dose coefficients (DgNCT ). This work aimed at computing, for a simple breast model, a set of DgNCT values for monoenergetic and polyenergetic X-ray beams, and at validating the results vs. those for patient specific digital phantoms from BCT scans. Methods: We developed a Monte Carlo code for calculation of monoenergetic DgNCT coefficients (energy range 4.25–82.25 keV). The pendant breast was modelled as a cylinder of a homogeneous mixture of adipose and glandular tissue with glandular fractions by mass of 0.1%, 14.3%, 25%, 50% or 100%, enveloped by a 1.45 mm-thick skin layer. The breast diameter ranged between 8 cm and 18 cm. Then, polyenergetic DgNCT coefficients were analytically derived for 49-kVp W-anode spectra (half value layer 1.25–1.50 mm Al), as in a commercial BCT scanner. We compared the homogeneous models to 20 digital phantoms produced from classified 3D breast images. Results: Polyenergetic DgNCT resulted 13% lower than most recent published data. The comparison vs. patient specific breast phantoms showed that the homogeneous cylindrical model leads to a DgNCT percentage difference between −15% and +27%, with an average overestimation of 8%. Conclusions: A dataset of monoenergetic and polyenergetic DgNCT coefficients for BCT was provided. Patient specific breast models showed a different volume distribution of glandular dose and determined a DgNCT 8% lower, on average, than homogeneous breast model.